Introducing the highly anticipated Fourth Edition of Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, published by WOLTERS KLUWER HEALTH. This edition has gained recognition as a Doody’s Core Title for 2022 and 2023 and was honored as a highly commended title by the British Medical Association at the 2017 BMA Medical Book Awards. This esteemed text is regarded by both students and instructors for its comprehensive and integrated approach to pharmacology.

The Fourth Edition presents a unique mechanism-based and systems-based methodology that caters especially to first- and second-year students. It is meticulously designed to simplify complex concepts, enabling students to grasp them quickly and efficiently. Each chapter is crafted to include a clinical vignette that illustrates a specific therapeutic problem within a physiologic or biochemical system. This is followed by an in-depth discussion of the underlying biochemistry, physiology, and pathophysiology of the system. Finally, the chapter concludes with a detailed presentation of the pharmacology of various drugs and drug classes that activate or inhibit the system through interactions with specific molecular and cellular targets.

The content is logically organized into sections that emphasize organ systems and therapeutic areas of the highest importance, ensuring that students receive a well-rounded education in pharmacology. To aid in understanding, clear and concise illustrations highlight key points throughout the text. Additionally, drug summary tables provide quick access to essential information, enhancing the learning experience.

This Fourth Edition is an essential resource for anyone seeking to deepen their understanding of pharmacology. With its structured approach, engaging content, and visual aids, it stands out as a key educational tool in the field. Embrace the opportunity to expand your knowledge and enhance your studies with this comprehensive text.